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. 2015 Jul 6;10(7):e0131716. doi: 10.1371/journal.pone.0131716

Fig 1. A-366 has cellular activity comparable to known G9a/GLP inhibitors.

Fig 1

(A) The chemical structure of A-366. (B) PC-3 prostate adenocarcinoma cells were incubated in triplicate with DMSO or the indicated concentrations of A-366 or UNC0638 for 72 hours. H3K9me2 levels were assessed by In-Cell Western assay. (C) In-Cell Western assay for total histone H3 levels from the same plate as shown in (B).