Table 1. Overview of performed mouse experiments.

Experi-ment	Transgene	Number of mice	% transgene positive cells (PB, 5–8 weeks post Tx)	Observation time (weeks)	Final diagnosis
1	dnMpl-IRES.GFP	5	2–22	29	thrombocytopenic
1	IRES.GFP*	5	27–38	29	healthy
2	dnMpl	10	21–53	16	thrombocytopenic
2	trCD34	10	33–71	16	healthy
3	dnMpl- IRES.GFP	5	65–75	23**	thrombocytopenic
3	cd-dnMpl- IRES.GFP	5	66–75	23**	thrombocytopenic
3	IRES.GFP*	5	78–83	23**	healthy
4	dnMpl- IRES.GFP	20	56–73	8	Exp. terminated to collect LSK cells
4	IRES.GFP*	10	85–90	8	Exp. terminated to collect LSK cells
5	dnMpl- IRES.GFP	4	1–14	19+20***	Sec. BM transplant into same recipient
5	IRES.GFP*	4	7–25	19+20***	Sec. BM transplant into same recipient

*IRES.GFP mice of the control group are named GFP throughout the manuscript.

** Two mice of each group were transplanted with a second BM graft (2 x 10⁷ cells) 19 weeks after the first transplantation and followed for additional 16 weeks.

*** All mice were transplanted with a second BM graft (2 x 10⁷ cells) 19 weeks after the first transplantation and followed for additional 20 weeks