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. 2015 Jul 6;10(7):e0132333. doi: 10.1371/journal.pone.0132333

Fig 2. CD4T contributes to T cell activation.

Fig 2

(A) 58α-β- T cell hybridomas were retrovirally transduced with the 5c.c7 TCR and either CD4WT, CD4T or no CD4. IL-2 secretion from CD4T 58α-β- T cell hybridomas after 16 hours of co-culture with MCC:I-Ek+ M12 cells was normalized to the matched no CD4 controls within the same experiment to determine a relative IL-2 concentration. Bars represent mean values +/- SEM from four independently generated matched sets of cell lines. (B) IL-2 secretion after 16 hours of co-culture with MCC:I-Ek+ M12 cells normalized to matched CD4WT controls within the same experiment to determine relative IL-2 concentration. Bars represent mean values +/- SEM from four independently generated matched sets of cell lines. (*p<0.05; Mann-Whitney).