Table 1. Characteristics of studies included in the meta-analysis.
Prevention Group | Control Group | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Studies | Risk Factor | Co-administration | Course | n | Drug | Usage | Ulcer/ Erosion(%) | Bleeding (%) | n | Drug | Usage | Ulcer/ Erosion(%) | Bleeding (%) |
Ng 2010[48] | Ulcer or erosions | no | 48w | 65 | pantoprazole | 20 mg bid | 0 (0) | 0 (0) | 65 | famotidine | 40mg bid | 8 (12.3) | 5 (7.7) |
Ng 2012[49] | ACS or MI | Clopidogrel and anticoagulant | 4-52w | 163 | esomeprazole | 20 mg qd | 1 (0.6) | 3 (1.8) | 148 | famotidine | 40 mg qd | 6 (4.1) | 12 (8.1) |
Yano 2012[50] | ACS | Clopidogrel | 12m | 65 | Omeprazole | 10 mg qd | - | 3(4.6) | 65 | famotidine | 20 mg qd | - | 1(1.5) |
Guo M 2009[51] | Not clear | no | 90d | 42 | Omeprazole or esomeprazole | 20 mg qd | 6 (14.3) | - | 22 | famotidine | 20 mg bid | 5 (22.7) | - |
Sun RR 2012[52] | Elders | no | 90d | 40 | rabeprazole | 20 mg qd | 3 (7.5) | 0 (0) | 40 | ranitidine | 150mg bid | 11 (27.5) | 1(2.5) |
Wang YP 2012[53] | HP-, no ulcer history | no | 90d | 23 | lansoprazole | 30 mg qd | 2 (8.7) | 0 (0) | 22 | famotidine | 20 mg bid | 6 (27.3) | 1(4.5) |
Hu L 2012[54] | Not clear | no | 90d | 50 | rabeprazole | 10 mg qd | 5(10) | - | 48 | famotidine | 20 mg bid | 9 (18.8) | - |
Lu BJ 2013[55] | ACS | Clopidogrel | 30d | 50 | omeprazole | 40mg qd | - | 2(4) | 50 | ranitidine | 150 mg bid | - | 9(18) |
Wang J 2012[56] | ACS | Clopidogrel | 90d | 43 | esomeprazole | 20mg bid | 3 (7.0) | - | 46 | famotidine | 20 mg bid | 5 (10.9) | - |
ACS:acute coronary syndrome; MI:myocardial infarction