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In G1 phase, Rev1 is abundant and Rev1-dependent loading of TLS polymerase may occur. At the onset of S phase, Rev1 is destroyed in a SCF-dependent manner and chromatin-loaded Eso1/polη serves as an initiator of TLS. When DNA is damaged, the DNA structure checkpoint increases the protein level of Rev1 and facilitates polymerase switching among TLS polymerases.
