Table 4.
Heritability of MetS
| Trait | Heritability (%) | p value* | Covariatesa (%) |
|---|---|---|---|
| MetSb | 48 | 1.62 × 10−25 | 24 |
| BP + HDL + TRIG | 53 | 5.80 × 10−9 | 21 |
| BP + HDL + WAIST | 52 | 2.00 × 10−7 | 10 |
| BP + HDL + TRIG + WAIST | 34 | 0.003 | 19 |
| BP + GLU + WAIST | 17 | 0.09 | 14 |
| BP + HDL + WAIST + TRIG + GLU | 58 | 0.001 | 28 |
| SBP (mmHg) | 29 | 2.04 × 10−53 | 27 |
| DBP (mmHg) | 20 | 2.35 × 10−31 | 9 |
| HDL (mg/dL) | 60 | 7.72 × 10−221 | 10 |
| TRIGc (mg/dL) | 35 | 4.28 × 10−72 | 6 |
| WAIST (cm) | 41 | 1.74 × 10−70 | 29 |
| GLUd (mg/dL) | 31 | 2.72 × 10−58 | 38 |
The 9,647 individuals in this study sample were included into 589 pedigrees counting 16,463 members (mean size, 27.9 subjects).
BP blood pressure, DBP diastolic blood pressure, GLU fasting plasma glucose, HDL high density lipoprotein cholesterol, SBP systolic blood pressure, TRIG triglycerides, WAIST waist circumference.
aFor quantitative traits it represents the percentage of variance explained by covariates, for dichotomous trait it represents Kullback–Leibler R-squared.
bMetS as a dichotomous trait, according to the NCEP-ATPIII definition.
cLogarithmic transformation has been applied.
d reciprocal transformation has been applied.
* Two sided p value for testing the null hypothesis that heritability = 0.