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. 2015 Jun 23;2015:659378. doi: 10.1155/2015/659378

Figure 2.

Figure 2

CTM reduced TGF-β1 expression profile in the liver of Sj-infected mice. tTG activity of BABL/c mouse liver was inhibited by CTM intraperitoneal injection from day 3 to day 10 after Sj infection. Mice were sacrificed at week 8 after infection. (a) Activated TGF-β1 concentration in mouse serum of normal or Sj-infected mice with or without CTM treatment was detected using ELISA. Data were presented as mean ± SD from 10 mice per each group. ∗ P < 0.05; and ∗∗ P < 0.01. (b) Activated TGF-β1 protein levels in mouse liver of normal or Sj-infected mice with or without CTM treatment were detected by Western blot analysis, and GAPDH was used as the internal control. (c) Mouse liver samples collected at indicated time points were fixed in paraformaldehyde, embedded in paraffin, sliced, and immunohistochemically stained for TGF-β1. Representative stainings for TGF-β1 were shown at 40x magnification. Bottom: TGF-β1 expression in egg, Sj egg granuloma, and the surrounding tissue. Top: TGF-β1 expression in hepatic cell and liver tissue around the liver sinusoid; “−” = without, “+” = with.