Table 3.

Performance characteristics of an auto-populating electronic Pulmonary Embolism Severity Index

Index Variable	Values n	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Accuracy % (95% CI)	Cases needing editing (N=593) N (%; 95% CI)	Reason for prevalent inaccuracies
All 11 variables	6,523	96.9 (96.0–97.9)	99.8 (99.7–99.9)	99.1 (98.6–99.6)	99.2 (99.0–99.5)	99.2 (99.0–99.4)	47 (7.9; 6.0–10.4)
Demographics	1,186	100.0	100.0	100.0	100.0	100.0 (99.6–100.0)	0 (0; 0–0.8)
Age	593	100.0	--	100.0	--	100.0 (99.2–100.0)
Sex (male)	593	100.0	100.0	100.0	100.0	100.0 (99.2–100.0)
Comorbidities	1,779	87.1 (82.2–92.0)	99.4 (99.0–99.8)	93.9 (90.3–97.6)	98.6 (98.0–99.2)	98.1 (97.4–98.7)	33 (5.6; 4.0–7.7)	Problem List incomplete or erroneous
Cancer	593	70.0 (53.6–86.4)	99.8 (99.5–100.0)	95.5 (86.8–100.0)	98.4 (97.4–99.4)	98.3 (96.9–99.1)
Heart failure	593	83.3 (72.1–94.6)	99.6 (99.1–100.0)	94.6 (87.3–100.0)	98.7 (97.8–99.7)	98.5 (97.1–99.3)
Chronic lung disease	593	93.4 (88.7–98.1)	98.6 (97.5–99.6)	93.4 (88.7–98.1)	98.6 (97.5–99.6)	97.6 (96.0–98.6)
Vital signs	2,965	95.3 (92.8–97.9)	100.0	99.6 (98.8–100.0)	99.6 (99.3–99.8)	99.6 (99.2–99.8)	13 (2.2; 1.3–3.8)	Inaccessibility of pre-arrival and unstructured values
Pulse	593	99.1 (97.2–100.0)	100.0	100.0	99.8 (99.3–99.8)	99.8 (98.9–100.0)
Systolic blood pressure	593	97.0 (92.9–100.0)	100.0	100.0	99.6 (99.1–100.0)	99.7 (98.7–100.0)
Respiratory rate	593	100.0	100.0	100.0	100.0	100.0 (99.2–100.0)
Temperature	593	100.0	100.0	100.0	100.0	100.0 (99.2–100.0)
Arterial oxygen saturation	593	81.6 (70.8–92.5)	99.8 (99.5–100.0)	97.6 (92.8–100.0)	98.4 (97.3–99.4)	98.3 (96.9–99.1)
Altered mental status (AMS)	593	44.4 (12.0–76.9)	100.0	100.0	99.2 (98.4–99.9)	99.2 (98.0–99.7)	5 (0.8; 0.3–2.0)	Insensitivity of our AMS identification formula

Sens, sensitivity; Spec, specificity; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval