Table 1.
Inhibition of europium-labeled insulin (Eu-insulin) for binding to the IR-A.
| Insulin | IGF-II | qIGF-I | S597 | |
|---|---|---|---|---|
| IC50 (nM) | 1.57 ± 0.33 | 15.21 ± 0.18 | 4.88 ± 0.8 | 0.75 ± 0.16 |
| Rel. IC50 (%) | 100 | 10.3 | 32.2 | 209 |
The concentration at which 50% of Eu-insulin binding was inhibited by each peptide (IC50 nM) is given. The IC50 relative to that of insulin is also shown. Values are the means ± SEM of three independent experiments.