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. 2015 May 27;4(2):218–233. doi: 10.3390/cells4020218

Figure 3.

Figure 3

Deficiency of Prkcι/ξ disrupts nephron epithelial polarity. (A) At the 22 ss, actin is mislocalized in Prkcι/ξ deficient embryos, though lumen formation eventually occurs by 36 hpf, accompanied by normal laminin distribution at the basal lamina though Na+/K+ ATPase distribution remains mislocalized at this time point. (B) Summary of phenotypes in Prkcι/ξ deficient embryos compared to wild-type embryos. Abbreviations: hours post fertilization (hpf), mesenchymal to epithelial transition (MET), morpholino (MO) somite stage (ss). [Figure adapted from Reference [57], through terms of the Creative Commons License of the Authors].