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. 2015 May 27;4(2):218–233. doi: 10.3390/cells4020218

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Model of mecom functions in nephron segmentation. mecom expression is proposed to promote DL formation and inhibit PST fates during proximodistal segment patterning. These activities act in opposition to RA signaling, which promotes PCT and PST formation and has been speculated to inhibit distal fates. Abbreviations: distal early (DE), distal late (DL), intermediate mesoderm (IM), proximal convoluted tubule (PCT), pronephric duct (PD), proximal straight tubule (PST), retinoic acid (RA). [Figure adapted from [68], through terms of the Creative Commons License of the Authors].