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. 2015 May 27;4(2):218–233. doi: 10.3390/cells4020218

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Model of sim1a functions in nephron segmentation. sim1a is necessary to promote PST and CS formation and inhibit PCT fates during segment patterning in the zebrafish pronephros. These activities occur downstream of RA signaling, which promotes PCT and PST formation and expression of sim1a in these respective renal progenitor domains. Further, RA signaling inhibits sim1a expression in CS progenitors, placing it as a negative regulator upstream of sim1a during establishment of the CS lineage. Abbreviations: corpuscle of Stannius (CS), distal early (DE), distal late (DL), neck (N), podocytes (P), proximal convoluted tubule (PCT), pronephric duct (PD), proximal straight tubule (PST), retinoic acid (RA). [Figure adapted from [45], through terms of the Creative Commons License of the Authors].