Table 3.
Summary of conditions that induce fibroblastic transformation of corneal keratocytes.
| Culture media | Uncompressed 3-D collagen ECM | Fibrillar collagen on glass (2-D) | Compressed 3-D collagen ECM | |||
|---|---|---|---|---|---|---|
| (↓ Stiffness, ↓ Collagen density) | (↑ Stiffness, ↓ Collagen density) | (↑ Stiffness, ↑ Collagen density) | ||||
| Control | Rac1 inhibitor | Control | Rac1 inhibitor | Control | Rac1 inhibitor | |
| Serum-Free | No | No | No | No | No | Yes |
| PDGF | No | No | No | Yes | No | Yes |
| IGF | No | No | No | No | No | Yes |
| FGF | No | No | Yes | Yes | Yes | Yes |
| TGFβ1 | Yes | Yes | Yes | Yes | Yes | Yes |