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. 2015 May 23;5(9):946–960. doi: 10.7150/thno.11974

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Photographs (top) and x-ray images (bottom) of mice before and after photothermal therapy with tumors circled in red. The control mouse images were taken 7 days after treatment and the images of the mouse with GNS injection were taken 3 days after treatment. Dark discoloration in the tumor region for the GNS mouse is due to nanoparticle accumulation in the underlying tumor. X-ray images show a clear decrease in tumor bulk for the mouse with GNS injection, but a significant increase in tumor size for the mouse with PBS injection. Similar results were obtained for the second mouse tested in each group.