Figure 3.

Displacement with unlabelled TSPO ligands for [¹⁸F]FEBMP uptake. A-C: Representative coronal PET summation images (A; 0-20 min, B; 30-90 min) of [¹⁸F]FEBMP and the time-activity curve (C; mean ± SEM, n = 3) in an ischemic rat model that received additional treatment with unlabelled MBMP at 20 min after [¹⁸F]FEBMP bolus injection. D-F: Representative coronal PET summation images (D; 0-20 min, E; 30-90 min) of [¹⁸F]FEBMP and the time-activity curve (F; mean ± SEM, n = 3) in a rat model of ischemia. The rat received additional treatment with unlabelled PK11195 at 20 min after [¹⁸F]FEBMP bolus injection. Ipsilateral and contralateral indicate ipsilateral and contralateral sides of the ischemic brain in the striatum.