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Scheme of systematic enrichment of aptamers against PDAC PL45 cell line. The DNA library was incubated with hTERT-HPNE cells (negative cells) to remove negative cell-binding sequences. The unbound DNAs were collected and then incubated with target PL45 cell line for positive selection. After washing, the bound DNAs were eluted and amplified by PCR for next-round selection. After enrichment, DNA sequencing was performed to identify individual aptamer sequences.
