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. 2015 Jul 7;5:11872. doi: 10.1038/srep11872

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Copyright © 2015, Macmillan Publishers Limited

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(a, b) Flow cytometric analysis showed that the number of CCR2⁺ CD11b⁺ cells and CCR2⁺ CD11c⁺ cells was highly increased in the RPE-choroid at day 3 after laser injury, and significantly reduced by an intravitreal injection of TSG-6. (c-e) Further analysis after gating on CCR2 revealed that the number of CCR2⁺ CD11b⁺ CD11c⁺ cells and CCR2⁺ CD11b⁻CD11c⁺ cells in the RPE-choroid was significantly decreased by TSG-6 treatment. However, the number of CCR2⁺ CD11b⁺ CD11c⁻ cells was not altered by laser injury or TSG-6 treatment. (f) Real-time RT PCR showed that the expression of CCL2 in the RPE-choroid was significantly suppressed by TSG-6 treatment. n = 4 in each group. Data are presented as mean + SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ns: not significant.