Table 1. Morphometric and metabolic parameters.
| 9-wk | 11-wk | 13-wk | 15-wk | 17-wk | |
|---|---|---|---|---|---|
| Body weight, g | |||||
| wildtype mice | 22.59 ± 0.35 | 19.91 ± 0.28 | 20.35 ± 0.31 | 20.88 ± 0.32 | 22.21 ± 0.34 |
| db/db mice | 41.14 ± 0.96** | 40.34 ± 1.09** | 42.35 ± 1.14** | 45.36 ± 1.24** | 50.85 ± 0.96** |
| Serum glucose, mmol/L | |||||
| wildtype mice | 6.31 ± 0.35 | 4.92 ± 0.33 | 5.20 ± 0.34 | 6.56 ± 0.89 | 4.93 ± 0.11 |
| db/db mice | 17.08 ± 0.88** | 20.72 ± 2.15** | 17.33 ± 1.00** | 12.94 ± 0.83** | 10.49 ± 0.35** |
| CRE, mg/dL | |||||
| wildtype mice | 10.52 ± 0.48 | 14.51 ± 1.57 | 14.35 ± 1.81 | 16.95 ± 1.89 | 19.14 ± 2.33 |
| db/db mice | 6.02 ± 0.81** | 4.68 ± 0.55** | 4.50 ± 0.53** | 3.80 ± 0.64** | 3.48 ± 0.71** |
| UACR, mg/mmol | |||||
| wildtype mice | 56.57 ± 5.92 | 83.77 ± 12.15 | 77.82 ± 10.86 | 65.76 ± 5.93 | 65.13 ± 8.95 |
| db/db mice | 95.47 ± 6.50** | 135.00 ± 18.57* | 131.37 ± 18.57* | 138.28 ± 19.68** | 153.62 ± 27.06* |
Values are expressed as mean ± SE; Keys: CRE, urine creatinine; UACR, urinary albumin to creatinine ratio; *P < 0.05, **P < 0.01 compared with age-matched wildtype mice.