Table 2. Summary of immunohistochemistry data for cervical samples and clinical value of RIPK4, p16INK4a and Ki-67 in relationship to diagnoses of HSIL.
| Chronic cervicitis | LSIL | HSIL | Pa | HSIL vs. LSIL + chronic cervicitis | |||
|---|---|---|---|---|---|---|---|
| Biomarkers | N (%) | N (%) | N (%) | Se | Sp | YI | |
| RIPK4+ | 2/63 (3.2) | 21/109 (19.3) | 120/141 (85.1) | <0.001 | 85.1 | 86.6 | 71.7 |
| p16INK4a+ | 8/59 (13.6) | 48/107 (44.9) | 128/139 (92.1) | <0.001 | 92.1 | 66.3 | 58.4 |
| Ki-67+ | 9/60 (15.0) | 38/106 (35.8) | 113/140 (80.7) | <0.001 | 80.7 | 71.7 | 52.4 |
| RIPK4+ and p16INK4a + | 0/57 (0) | 9/103 (8.7) | 110/139 (79.1) | <0.001 | 79.1 | 94.4 | 73.5 |
| RIPK4+ or p16INK4a + | 10/57 (17.5) | 56/103 (54.4) | 137/139 (98.6) | <0.001 | 98.6 | 58.8 | 57.4 |
| p16INK4a + and Ki-67+ | 2/57 (3.5) | 31/104 (29.8) | 110/138 (79.7) | <0.001 | 79.7 | 79.5 | 59.2 |
| p16INK4a + or Ki-67+ | 13/57 (22.8) | 51/104 (49.0) | 130/138 (94.2) | <0.001 | 94.2 | 60.2 | 54.4 |
| RIPK4+ and Ki-67+ | 0/59 (0) | 6/103 (5.8) | 102/140 (72.9) | <0.001 | 72.9 | 96.3 | 69.2 |
| RIPK4+ or Ki-67+ | 10/59 (16.9) | 51/103 (49.5) | 129/140 (92.1) | <0.001 | 92.1 | 62.3 | 54.4 |
Abbreviations: LSIL low-grade squamous intraepithelial lesion; HSIL high-grade squamous intraepithelial lesion; Se sensitivity; Sp specificity; YI Youden’s index.