Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Molecular mechanisms of chronic disease progression in which persistent or increased ROS/damage load and/or decreased levels of NAD+ drive the transition from AMPK/PGC-1α/FOXO3a-linked repair responses towards pro-inflammatory responses controlled by the mTOR/HIF-1α/NF-κB axis. See text for further explanation
