Fig. 1.

Representation of the interactomes of a prototypical splicing activator, SRSF1, and a prototypical splicing repressor, HNRNPA1. Akerman and colleagues [3] report that activators — which promote exon inclusion (shown at right) — form more interactions with components of the spliceosome than repressors, which promote exon exclusion (left). EJC exon junction complex; hnRNP heterogeneous nuclear ribonucleoprotein; RBM RNA binding motif; SRSF serine/arginine-rich splicing factor