TABLE 2 ] .
Change From Baseline in Clinical Outcome Measures
| Measure | LVRS (n = 9) | BLVR Responders (n = 7) | All Successful LVR (n = 16) | Control Subjects (n = 10) | P Valuea |
| ΔFEV1, L | 0.38 ± 0.61 | 0.22 ± 0.22 | 0.31 ± 0.47 | –0.01 ± 0.11 | .03 |
| FEV1 % change | 33.6 ± 48.1 | 23.5 ± 20.7 | 29.2 ± 37.9 | –2.3 ± 12.5 | .03 |
| ΔFVC, L | 0.21 ± 0.82 | 0.57 ± 0.21 | 0.36 ± 0.64 | –0.14 ± 0.38 | .03 |
| ΔRV, L | –0.77 ± 0.71 | –1.23 ± 0.28 | –0.97 ± 0.60 | 0.04 ± 0.48 | .0001 |
| ΔFRC, L | –0.50 ± 0.47 | –0.84 ± 0.38 | –0.65 ± 0.45 | 0.17 ± 0.45 | .01 |
| ΔTLC, L | –0.57 ± 0.58 | –0.81 ± 0.42 | –0.67 ± 0.52 | –0.18 ± 0.36 | .002 |
| ΔRV/TLC | –6.3 ± 10.5 | –9.2 ± 2.9 | –7.6 ± 8.0 | 1.6 ± 4.3 | .0005 |
| Tlcoc, % change | 10.1 ± 20.0 | 9.9 ± 17.6 | 10.0 ± 18.3 | –2.1 ± 10.2 | .09 |
| ΔSGRQ, points | –15.7 ± 13.5 | –12.0 ± 20.2 | –14.1 ± 16.2 | 2.93 ± 9.76 | .002 |
| ΔmMRC, points | –0.78 ± 0.83 | –0.57 ± 0.79 | –0.69 ± 0.79 | –0.10 ± 0.74 | .12 |
| Δ6MWD, m | 30.5 ± 49.4 | 64.9 ± 46.8 | 46.5 ± 49.7 | –21.3 ± 97.3 | .04 |
| ΔTlim, s | 180 ± 256 | 157 ± 291 | 196 ± 23 | –51.5 ± 158 | .04 |
| ΔEELV isotime, L | –0.69 ± 0.73 | –1.05 ± 0.75 | –0.86 ± 0.73 | –0.09 ± 0.84 | .03 |
Data are presented as mean ± SD. LVR = lung volume reduction. See Table 1 legend for expansion of other abbreviations.
a
Unpaired t tests or Mann-Whitney test comparing the change from baseline between all LVR responders (LVRS and BLVR responders) vs control subjects. No significant difference was seen between LVRS and BLVR responder groups.