Table 2. Antiproliferative Activities of 3a–j^a.

	GI50 (μM)
compd	A549	MCF-7	MDA-MB-231	MDA-MB-468
3a	0.29 ± 0.01	0.14 ± 0.03	0.37 ± 0.13	0.22 ± 0.07
3b	0.95 ± 0.77	1.72	1.00 ± 0.58	1.62 ± 0.48
3c	2.44 ± 0.40	2.30 ± 0.67	4.61 ± 2.20	1.82 ± 0.20
3d	2.32 ± 0.35	2.66 ± 1.30	5.82 ± 4.61	2.32 ± 0.39
3e	>100	>100	>100	13.74 ± 3.98
3f	0.26 ± 0.06	1.65 ± 0.44	0.26 ± 0.04	0.20 ± 0.02
3g	39.15 ± 32.09	28.99 ± 10.27	82.67 ± 24.52	10.19 ± 1.47
3h	1.16 ± 0.05	0.81 ± 0.78	1.21 ± 0.15	0.25 ± 0.01
3i	0.47 ± 0.06	0.31 ± 0.10	0.073 ± 0.04	0.046 ± 0.04
3j	2.17 ± 0.11	1.89 ± 0.60	2.71 ± 0.32	1.85 ± 0.23

^aGI₅₀ is the concentration required to inhibit the cancer cell growth by 50% as evaluated by the MTT assay. The compounds were incubated with cells for 72 h. The GI₅₀ was presented as mean ± SD of at least two independent experiments in duplicates or >100 in the cases where GI₅₀ was not reached at the highest tested concentration (100 μM). When SD was not presented, only one experiment was performed in duplicate.