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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: J Nat Sci. 2015;1(7):e131.

Figure 1. A model illustrating the negative regulation of p53 by LIF that contributes to chemoresistance in human colorectal cancer cells.

Figure 1

LIF binds to LIF receptor complex to activate the Stat3 signaling pathway. Stat3 transcriptionally induces inhibitor of DNA binding 1 (ID1), which can up-regulate MDM2, a key negative regulator of p53. The increased MDM2 levels promote p53 protein degradation, which leads to decreased p53 protein levels and reduced function in apoptosis. In turn, LIF promotes chemoresistance in human colorectal cancer cells.