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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Free Radic Biol Med. 2014 Mar 6;71:402–414. doi: 10.1016/j.freeradbiomed.2014.02.023

Figure 4. Proliferator–activated receptor co-activator-1-alpha (PGC1α) is activated in response to acute exercise stress in skeletal muscle.

Figure 4

A-B) Analysis of nuclear levels of PGC1α and Nrf1 in WT and Nrf2-null mice under sedentary and AEES conditions at >23 months of age. Representative Immunoblotting (IB) experiments from nuclear extracts were performed using anti-PGC1α and anti-Nrf1 and lmin-B (A), and anti-IkBα, IkBβ, and GAPDH antibodies (n=4/group.). In sedentary mice, PGC1α levels were decreased in Nrf2-null versus WT mice. AEES augmented the PGC1α and IkBα/β levels in both genotypes. Each lane indicates an individual mouse. Protein blots/values represent n=4 or more mice from each group. *p<0.05; **p<0.01 between WT-SED vs. other experimental groups.