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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Free Radic Biol Med. 2014 Mar 6;71:402–414. doi: 10.1016/j.freeradbiomed.2014.02.023

Figure 8. AEES and loss of Nrf2 diminishes stem cell lineage and muscle regeneration in Nrf2-null mice.

Figure 8

Abrogation of Nrf2 and AEES modulates the expression of stem cell and muscle regeneration factors (PAX7 and MYOD). (A) Representative immunoblots showing significantly diminished PAX7 and MYOD proteins in SM of Nrf2-null versus WT mice in response to AEES (n=4/group; *p<0.05). (B) Immunofluorescence analyses of PAX7 positive myocytes from WT and Nrf2-null mice (n=3 mice/group; *p<0.05 vs. WT-SED). C. Histograms of regeneration ability for WT and Nrf2-null mice were determined by calculating the percent of myocytes with active nuclei. Decreased satellite cell population is evident in Nrf2-null in response to AEES. Green – PAX7 positive; red – laminin and blue – DAPI/nucleus.