Table 3.
Long-term effect of quantity and quality of dietary fat on proteome of cytoplasmic fraction of PBMC
| Proteomic changes Induced after 12 weeks of the intake of HSFA diet consumption | |||
| Protein | Symbol | FC | p-Value |
| - Target of Myb protein 1 | TOM1 | 2.06 | 0.027 |
| - DNA-directed RNA polymerase III subunit | POLR3E | 3.08 | 0.012 |
| - Chain A, X-Ray Crystal Structure Of Zinc-Bound F95mW97V CARBONIC Anhydrase (Caii) Variant | UR | 0.017 | |
| - Coiled-coil domain-containing protein 88B. Isoform 3 | CCDC88B | DR | 0.026 |
| Proteomic changes Induced after 12 weeks of the intake of HMUFA diet consumption | |||
| Protein | Symbol | FC | p-Value |
| - Chloride intracellular channel 1 protein | CLIC1 | 0.63 | 0.032 |
| - Protein disulfide isomerase-related protein 5 | PDIA5 | 0.47 | 0.008 |
| - Capping protein (actin filament) muscle Z-line, beta | CAPZ | 0.32 | 0.024 |
| - hCG1808619 | DR | 0.024 | |
| - Nuclear receptor-interacting protein 3 | NRIP3 | DR | 0.023 |
| - Zinc finger protein 791 | ZFP791 | 1.89 | 0.038 |
| Proteomic changes Induced after 12 weeks of the intake of LFHCC diet consumption | |||
| Protein | Symbol | FC | p-Value |
| - hCG2041202 | 0.62 | 0.001 | |
| - NF-kappa-B-activating kinase | TBK1 | 0.62 | 0.019 |
| - Growth factor receptor-bound protein 2 isoform 1 | GRB2 | 0.35 | 0.026 |
| - Sry-related HMG box gene | 0.16 | 0.007 | |
| - PSMA4 protein | PSMA4 | 1.81 | 0.071 |
| - Voltage-dependent anion channel 2, isoform CRA_a | VDAC2 | 0.70 | 0.046 |
| Proteomic changes Induced after 12 weeks of the intake of LFHCC + n3 diet consumption | |||
| Protein | Symbol | FC | p-Value |
| - Vacuolar protein sorting-associated protein 28 homol | VPS28 | 1.85 | 0.040 |
| - BiP Protein | BiP | 1.77 | 0.029 |
| - Chloride intracellular channel 1 protein | CLIC1 | 0.40 | 0.013 |
| - Beta actin | ACTB | DR | <0.05 |
| - POTE-2 alpha actin | POTE-2 | 0.38 | 0.014 |
| - Capping protein (actin filament) muscle Z-line, beta | CAPZ | DR | <0.05 |
| - HSP70-2 | HSP70-2 | 0.35 | 0.049 |
| - Microtubule-actin cross-linking factor 1 | MACF1 | DR | <0.05 |
| - S4-SRCRB | 4.05 | 0.009 | |
| - Gelsolin | GSN | 1.67 | 0.023 |
Proteins differentially expressed in the post-intervention compared to the baseline from an average of over 350 protein spots detected in the cytoplasmic fraction. FC: Fold change. T-test p-value. UR, up-regulated proteins, not detected at baseline but detected at post-intervention. DR, down- regulated, proteins detected at baseline but not detected at post-intervention