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. 2015 Jul 6;210(1):153–168. doi: 10.1083/jcb.201503019

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© 2015 Gomez-Sanchez et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Outline of myelinophagy. (left) A transverse section through a myelin Schwann cell in an uninjured nerve. Note that the myelin sheath is in direct continuity with the Schwann cell membrane and an integral component of the Schwann cell. (right) A myelin Schwann cell after nerve injury and axonal degeneration. Note that the myelin sheath has broken up into myelin fragments lying in the Schwann cell cytoplasm. The proposed role of autophagy in digesting these fragments is illustrated.