Table 1.
CPs for membrane properties
| n | RMP (mV) | AP Amp (mV) | AP Thresh (mV) | Rin (MΩ) | τ (ms) | AP width (ms) | Sag (mV) | ΔmV (mV/10 pA) | |
|---|---|---|---|---|---|---|---|---|---|
| Ctrl (P23) | 24 | −64.5 ± 0.6 | 97.5 ± 2.2 | −31.8 ± 1.2 | 141 ± 12 | 11.5 ± 1.2 | 1.2 ± 0.1 | 1.4 ± 0.1 | 1.7 ± 0.1 |
| EP11-23 | 31 | −58.7 ± 0.5*** | 88.4 ± 1.9* | −26.5 ± 1.1* | 179 ± 10 | 19.1 ± 1.0 | 1.4 ± 0.0* | 2.1 ± 0.1** | 2.5 ± 0.3 |
| EP12-23 | 16 | −59.1 ± 0.7*** | 88.2 ± 2.7* | −26.1 ± 1.5 | 198 ± 14* | 24.0 ± 1.5** | 1.7 ± 0.1** | 2.4 ± 0.0*** | 3.0 ± 0.2** |
| EP13-23 | 19 | −61.1 ± 0.7* | 85.2 ± 2.4** | −28.7 ± 1.4 | 218 ± 13** | 19.2 ± 1.3 | 1.5 ± 0.1* | 2.5 ± 0.1*** | 2.9 ± 0.5** |
| EP14-23 | 28 | −63.5 ± 0.5 | 95.1 ± 2.4 | −32.4 ± 1.3 | 125 ± 11 | 8.3 ± 1.1 | 1.2 ± 0.1 | 0.8 ± 0.1 | 1.3 ± 0.1 |
| EP15-23 | 27 | −64.6 ± 0.6 | 96.4 ± 2.8 | −31.1 ± 1.3 | 144 ± 11 | 11.1 ± 0.6 | 1.3 ± 0.1 | 0.7 ± 0.0** | 1.4 ± 0.1 |
| EP16-23 | 10 | −65.0 ± 0.8 | 96.7 ± 2.0 | −31.4 ± 0.9 | 116 ± 14 | 10.8 ± 1.8 | 1.0 ± 0.1 | 0.8 ± 0.9* | 1.3 ± 0.1 |
| EP17-23 | 11 | −66.2 ± 0.8 | 95.1 ± 1.7 | −31.8 ± 0.6 | 106 ± 11 | 14.0 ± 1.4 | 1.1 ± 0.1 | 0.6 ± 0.6* | 1.2 ± 0.1 |
| Ctrl (P35) | 24 | −64.2 ± 0.5 | 99.1 ± 1.3 | −32.5 ± 1.0 | 118 ± 9 | 8.4 ± 0.8 | 1.0 ± 0.0 | 1.3 ± 0.1 | 1.5 ± 0.0 |
| EP18-35 | 25 | −66.4 ± 0.8 | 98.7 ± 2.0 | −32.5 ± 2.4 | 87 ± 6 | 11.1 ± 0.6 | 1.0 ± 0.1 | 1.3 ± 0.2 | 1.6 ± 0.2 |
| EP19-35 | 27 | −66.7 ± 0.7 | 106.3 ± 1.4 | −34.9 ± 1.2 | 134 ± 11 | 10.8 ± 1.8 | 1.1 ± 0.0 | 1.3 ± 0.0 | 1.6 ± 0.2 |
| EP23-35 | 44 | −65.0 ± 0.4 | 100.7 ± 1.4 | −33.4 ± 0.8 | 124 ± 7 | 8.5 ± 0.6 | 1.0 ± 0.0 | 1.3 ± 0.1 | 1.5 ± 0.0 |
RMP, resting membrane potential; AP amp, action potential amplitude; AP threshold, voltage threshold to spike; Rin, input resistance; τ, membrane time constant; AP width, action potential HW; Sag, depolarizing sag; ΔmV, change in membrane voltage per 10 pA step. EP, earplug insertion days.
*P < 0.05, **P < 0.01, ***P < 0.001.