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. 2015 May 7;7(6):1432–1454. doi: 10.1093/gbe/evv081

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© The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6.— — Patterns of conservation (A, C), expression (D), and creation during evolution (B) of human ESC-specific NANOG-binding sites (A, B) and LTR7/HERVH sequences (A, C, D) in individual genomes of five Modern Humans and three Neanderthals. (A) Patterns of the full-length sequence conservation of 826 human ESC-specific NANOG-binding sites (left panel) and 130 genomic loci encoding 33 nt LTR7 RNA (right panel) in genomes of five Modern Humans and three Neanderthals. (B) Estimates of creation rates of novel NANOG-binding sites during evolution. See table 4 and text for further details. (C) Representation in primates’ and rodents’ genomes of 128 LTR7/HERVH genomic loci with the most prominent expression in the H1 hESC cells. (D) Expression patterns in adult human tissues of 128 LTR7/HERVH genomic loci with the most prominent expression in the H1 hESC cells.

Fig. 6.— — Patterns of conservation (A, C), expression (D), and creation during evolution (B) of human ESC-specific NANOG-binding sites (A, B) and LTR7/HERVH sequences (A, C, D) in individual genomes of five Modern Humans and three Neanderthals. (A) Patterns of the full-length sequence conservation of 826 human ESC-specific NANOG-binding sites (left panel) and 130 genomic loci encoding 33 nt LTR7 RNA (right panel) in genomes of five Modern Humans and three Neanderthals. (B) Estimates of creation rates of novel NANOG-binding sites during evolution. See table 4 and text for further details. (C) Representation in primates’ and rodents’ genomes of 128 LTR7/HERVH genomic loci with the most prominent expression in the H1 hESC cells. (D) Expression patterns in adult human tissues of 128 LTR7/HERVH genomic loci with the most prominent expression in the H1 hESC cells.