Table 2.
Association of Human ESC-Specific NANOG-Binding Sites with Brain-Specific Genes that Are Rapidly Evolving in Primates, Housekeeping Protein-Coding Genes, and Pluripotency lncRNAs
| Genes | Number of Genes in the Genome | Number (%) of Genes Associated with Human-Specific NANOG-Binding Sites | Number of Associated Human-Specific TF-Binding Sites | Binding Site per Gene Ratio | Number (%) of Associated Human-Specific NANOG-Binding Sites | P Valuea |
|---|---|---|---|---|---|---|
| Brain-specific genes | 24 | 20 (83) | 115 | 5.8 | 86 (75) | ≪0.0001 |
| Housekeeping genes | 53 | 46 (87) | 214 | 4.7 | 176 (82) | ≪0.0001 |
| Pluripotency lncRNAs | 25 | 15 (60) | 26 | 1.7 | 23 (89) | 0.0059 |
| Lineage-specification lncRNAs | 34 | 14 (41) | 27 | 1.9 | 16 (59) | 0.0029b |
aHypergeometric distribution test.
bLess than expected by chance; <<0.0001 designates P = 0 at decimal place 30.