Table 3.

Association of Human ESC-Specific NANOG-Binding Sites with EDEs in hESCs

EDE Classification	Number of EDEs in the Genomea	Number (%) of Primate-Specific EDEs	Number of Human-Specific EDEs	Numberb of EDEs Close to Human-Specific NANOG-Binding Sites	P Valuec	Number of EDE-Associated Human-Specific NANOG-Binding Sites	P Valuec
Class I	5,116	1,157 (22.6)	6	31	1.89 E-06	36	9.21 E-09
Class II	2,285	421 (18.4)	1	14	0.000873	13	0.002296
Class II–I	195	16 (8.2)	0	1	0.291112	1	0.291112
Total	7,596	1,594 (21)	7	46	8.15 E-09	50	1.29 E-10

^aGenomic coordinates and classification of the EDEs were reported in Rada-Iglesias et al. (2011).

^bNumber of enhancers and binding sites with overlapping genomic coordinates within continuous 10-kb regions.

^cHypergeometric distribution test.