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. 2015 May 26;7(6):1743–1757. doi: 10.1093/gbe/evv102

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© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.— — Average segregation frequencies of TRAs to three antibiotic classes among bacteria residing within nine sampled environment types. (TRAs are defined as resistance alleles occurring within the housekeeping targets of antibiotics.) For each environment type, the average resistance allele frequency across all samples is depicted. Error bars represent standard deviations. (A) Frequency of TRAs to three broad-spectrum antibiotic classes: quinolones (green, TRAs found in the gyrA or parC genes), rifamycins (red, TRAs found in the rpoB gene), and streptomycin (blue, TRAs found in the rpsL gene). (B) Frequency of quinolone TRAs broken down by position within the GyrA/ParC protein sequences. Proportion of sequences carrying a quinolone TRA at any position is given in gray. Proportion of sequences carrying a quinolone TRA at position 83 of GyrA or 80 of ParC is given in red. Proportion of sequences carrying a quinolone TRA at position 87 of GyrA or 84 of ParC is given in blue.