Table 1.

Summary of Antibiotic Resistance Alleles Analyzed in This Study

Antibiotic	Gene	Resistance Allele	Known to Confer Resistance in (Citations)
Streptomycin	rpsL	43N	Proteobacteria (Silva et al. 2011; Angst and Hall 2013; Miskinyte and Gordo 2013), Actinobacteria (Okamoto-Hosoya et al. 2003)
		43R	Proteobacteria (Silva et al. 2011; Wang et al. 2011; Miskinyte and Gordo 2013), Deinococcus-Thermus (Carr et al. 2006), actinobacteria (Okamoto-Hosoya et al. 2003)
		88R	Actinobacteria (Okamoto-Hosoya et al. 2003; Wang et al. 2011), Proteobacteria (Angst and Hall 2013)
		88Q	Actinobacteria (Ballif et al. 2012), Proteobacteriajanne (Toivonen et al. 1999)
		91S	Proteobacteria (Paulander et al. 2009), Actinobacteria (Okamoto-Hosoya et al. 2003)
Rifamycins	rpoB	504N	Actinobacteria (Cavusoglu et al. 2002)
		511P	Actinobacteria (Williams et al. 1998)
		512F	Proteobacteria (Barrick et al. 2010; Qiu et al. 2012; Miskinyte and Gordo 2013)
		513L	Actinobacteria (Taniguchi et al. 1996)
		516G	Proteobacteria (Barrick et al. 2010), Actinobacteria (Williams et al. 1998)
		516Y	Proteobacteria (Barrick et al. 2010), Actinobacteria (Mokrousov et al. 2003)
		526Y	Proteobacteria (Miskinyte and Gordo 2013), Actinobacteria (Taniguchi et al. 1996; Paluch-Oles et al. 2009), Firmicutes (Mariam et al. 2004)
		526L	Actinobacteria (Williams et al. 1998)
		526P	Actinobacteria (Williams et al. 1998)
		529L	Actinobacteria (Makadia et al. 2012)
		529H	Proteobacteria (Miskinyte and Gordo 2013), Firmicutes (Watanabe et al. 2011)
		531F	Proteobacteria (Miskinyte and Gordo 2013), Actinobacteria (Taniguchi et al. 1996)
		564L	Proteobacteria (Qiu et al. 2012)
		572F	Proteobacteria (Miskinyte and Gordo 2013), Actinobacteria (Siu et al. 2011)
Quinolones	gyrA/parC	83/80F	Proteobacteria (Kehrenberg et al. 2009), Bacteroidetes (Oh et al. 2001), Actinobacteria (Eaves et al. 2002), Firmicutes (Ricci et al. 2004)
		83/80L	Proteobacteria (Silva et al. 2011), Actinobacteria (Eaves et al. 2002; Park et al. 2011; Silva et al. 2011), Bacteroidetes (Oh et al. 2001), Firmicutes (Janoir et al. 1996)
		83/80Y	Proteobacteria (Kehrenberg et al. 2009), Actinobacteria (Eaves et al. 2002), Firmicutes (Kaneko et al. 2000)
		87/84N	Proteobacteria (Saenz et al. 2003), Actinobacteria (Eaves et al. 2002), Firmicutes (de la Campa et al. 2004)
		87/84Y	Proteobacteria (Saenz et al. 2003; Kehrenberg et al. 2009; Silva et al. 2011), Bacteroidetes (Oh et al. 2001), Actinobacteria (Eaves et al. 2002), Firmicutes (de la Campa et al. 2004)
		87/84G	Proteobacteria (Saenz et al. 2003; Kehrenberg et al. 2009; Silva et al. 2011), Bacteroidetes (Oh et al. 2001), Actinobacteria (Eaves et al. 2002), Firmicutes (Janoir et al. 1996)