Fig. 1. A liver resection patient demonstrating vitamin K-associated anti-tumor effect on multiple HCC metastasis. A 50 year-old female patient showed lumbar spine metastasis 4 months after resection of two small HCC lesions. (A) Despite radiotherapy, bone metastasis aggravated. Multiple lung and intrahepatic metastases occurred with high rise of HCC tumor markers (AFP 2070 ng/ml and DCP 610 mAU/ml). (B, C) Transarterial chemoembolization was performed to the intrahepatic recurrence. (D) After oral vitamin K was administered for 6 month, intrahepatic metastasis disappeared, lung metastasis were regressed and bone metastasis was stationary, with normalization of all tumor markers.