Figure 11.

Proposed mechanisms underlying the effects of engineered ADMSC grafts on Improving angiogenesis and heart function and limiting the LV remodeling in a rat AMI model based on findings of the present study. ADMSC = adipose-derived mesenchymal stem cell; PRF = platelet-rich fibrin; BNP = brain natriuretic peptide; TGF = transforming growth factor; c-PARP = cleaved poly(ADP-ribose) polymerase; IL = interleukin; MMP = matrix metalloproteinase; SDF = stromal cell-derived factor; LVEDD = left ventricular end-diastolic dimension; LVEDV = left ventricular end-diastolic volume; VLESD = left ventricular end-systolic dimension; VLESV = left ventricular end-systolic volume; IVS = inter-ventricular septum. MHC = myosin heavy chain; LVEF = left ventricular ejection fraction.