Table 1.
Baseline characteristics and transthoraxic echocardiographic results of four groups at baseline and six-week after acute myocardial infarction
| Variables | Group 1 (n = 8) | Group 2 (n = 8) | Group 3 (n = 8) | Group 4 (n = 8) | p-value* |
|---|---|---|---|---|---|
| Final body weight (g) | 532 ± 38 | 525 ± 28 | 525 ± 24 | 538 ± 29 | 0.846 |
| Heart weight (g) | 1.49 ± 0.10 | 1.53 ± 0.15 | 1.52 ± 0.05 | 1.49 ± 0.07 | 0.784 |
| Left ventricle + septum | 0.95 ± 0.08 | 1.02 ± 0.09 | 1.01 ± 0.06 | 0.98 ± 0.04 | 0.323 |
| Ratio of heart weight to body weight | 0.0281 ± 0.00029 | 0.0292 ± 0.00019 | 0.0290 ± 0.00020 | 0.0286 ± 0.00023 | 0.618 |
| Echocardiograph (baseline) | |||||
| Thickness of IVS (mm) | 1.51 ± 0.17 | 1.54 ± 0.19 | 1.46 ± 0.15 | 1.57 ± 0.21 | 0.875 |
| Thickness of PW (mm) | 1.59 ± 0.28 | 1.67 ± 0.25 | 1.65 ± 0.22 | 1.61 ± 0.23 | 0.758 |
| LVEDD (mm) | 8.02 ± 0.92 | 7.99 ± 0.61 | 7.78 ± 0.24 | 7.83 ± 0.82 | 0.732 |
| LVESD (mm) | 4.78 ± 0.67 | 4.74 ± 0.94 | 4.84 ± 0.25 | 4.51 ± 0.75 | 0.851 |
| LVEDV (μL) | 368.3 ± 87.4 | 363.7 ± 72.1 | 325.8 ± 90.1 | 335.6 ± 73.9 | 0.810 |
| LVESV (μL) | 114.8 ± 44.3 | 109.5 ± 49.5 | 125.6 ± 30.7 | 95.8 ± 35.4 | 0.664 |
| LVFS (%) | 42.81 ± 4.19 | 42.01 ± 7.33 | 39.50 ± 2.43 | 42.01 ± 7.77 | 0.759 |
| LVEF (%) | 71.78 ± 4.56 | 70.57 ± 2.34 | 67.67 ± 2.34 | 70.50 ± 8.36 | 0.694 |
| Echocardiograph (at end of study period)† | |||||
| Thickness of IVS (mm) | 1.55 ± 0.17a | 0.88 ± 0.66b | 1.08 ± 0.11c | 1.11 ± 0.07c | < 0.001 |
| Thickness of PW (mm) | 1.58 ± 0.25 | 1.23 ± 0.17 | 1.44 ± 0.15 | 1.54 ± 0.51 | 0.785 |
| LVEDD (mm) | 8.21 ± 0.88a | 9.29 ± 0.58b | 8.79 ± 0.16c | 8.51 ± 0.19c | 0.005 |
| LVESD (mm) | 4.82 ± 0.51a | 7.19 ± 0.32b | 6.71 ± 0.41b,c | 6.27 ± 0.51c | < 0.001 |
| LVEDV (μL) | 387.4 ± 81.1a | 478.4 ± 49.1b | 438.5 ± 80.1c | 412.4 ± 53.5c | 0.003 |
| LVESV (μL) | 119.6 ± 40.3a | 273.8 ± 35.3b | 248.1 ± 41.3b,c | 184.3 ± 43.2c | < 0.001 |
| LVEF (%) | 68.6 ± 4.55a | 43.5 ± 4.41b | 47.9 ± 6.09b | 54.9 ± 5.24c | < 0.001 |
Data are expressed as % or mean ± SD. Group 1 = sham control; Group 2 = acute myocardial infarction (AMI) only; Group 3 = AMI + platelet-rich fibrin (PRF); Group 4 = AMI + PRF + adipose-derived mesenchymal stem cell (ADMSC). IVS = inter-ventricular septum; PW = posterior wall; LVEDD = left ventricular end-diastolic dimension; LVESD = left ventricular end-systolic dimension; LVEDV = left ventricular end-diastolic volume; LVESV = left ventricular end-systolic volume; LVEF = left ventricular ejection fraction.
indicates by one-way ANOVA.
Different letters (a, b, c) being used for grouping, indicating significant difference (< 0.05) among different groups by Bonferroni multiple-comparison post hoc test.
indicates the echocardiography was performed at day 42 after AMI induction.