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miR-29c overexpression can downregulate IGF-1 mRNA expression. Quantitative RT-PCR results revealed that miR-29c delivery markedly reduced the IGF-1-PI3K/AKT expression. (A) IGF-1, (B) PI3K, (C) AKT, and (D) VEGF mRNA expression. The upregulation of IGF-1 mRNA following miR-29c transfection in HUVECs was analyzed by RT-PCR (*p < 0.05, **p < 0.01).
