Table 6.
Cross-validation of methods and difference between sensitivity and specificity obtained before and after imputation
| Supervised imputation | Unsupervised imputation | |||||||
|---|---|---|---|---|---|---|---|---|
| Imputation method | Leave-one-out cross-validation accuracy of the imputation, % | Sensitivity difference before and after imputation, % | Specificity difference before and after imputation, % | Average absolute difference before and after imputation, % | Leave-one-out cross-validation accuracy of the imputation, % | Sensitivity difference before and after imputation, % | Specificity difference before and after imputation,% | Average absolute difference before and after imputation, % |
| 3NN | ||||||||
| Cytology | 96.70 | 2.68 | 0.02 | 1.35 | 96.70 | 2.68 | 0.02 | 1.35 |
| NMP22 | 83.44 | 3.30 | 0.41 | 1.86 | 83.19 | 3.30 | 0.29 | 1.80 |
| FISH | 83.17 | 7.42. | 1.70 | 4.56 | 85.49 | 1.80 | 0.99 | 1.40 |
| Cxbladder Detect | 81.44 | −1.38 | 0.67 | 1.03 | 80.44 | 1.99 | 3.03 | 2.51 |
| Mean for method | 86.19 | 3.01 | 0.70 | 2.20 | 86.46 | 2.44 | 1.08 | 1.76 |
| 5NN | ||||||||
| Cytology | 96.69 | 2.68 | 0.02 | 1.35 | 96.69 | 2.68 | 0.02 | 1.35 |
| NMP22 | 84.20 | 1.05 | −1.03 | 1.04 | 84.07 | 5.54 | −1.01 | 3.28 |
| FISH | 84.54 | 10.79 | −4.96 | 7.88 | 85.80 | 8.54 | −4.61 | 6.58 |
| Cxbladder Detect | 81.94 | −1.38 | −1.01 | 1.20 | 81.10 | 1.99 | 2.32 | 2.16 |
| Mean for method | 86.84 | 3.29 | −1.75 | 2.87 | 86.92 | 4.69 | −0.82 | 3.34 |
| 10NN | ||||||||
| Cytology | 96.69 | 2.68 | 0.02 | 1.35 | 96.69 | 2.68 | 0.02 | 1.35 |
| NMP22 | 86.09 | 1.05 | −1.36 | 1.21 | 85.84 | 5.54 | −1.12 | 3.33 |
| FISH | 86.12 | 10.79 | −4.13 | 7.46 | 85.80 | 16.40 | −3.06 | 9.73 |
| Cxbladder Detect | 82.44 | −1.38 | −2.74 | 2.06 | 81.77 | 0.87 | 0.20 | 0.53 |
| Mean for method | 87.84 | 3.29 | −2.05 | 3.02 | 87.53 | 6.37 | −0.99 | 3.74 |
| MLR | ||||||||
| Cytology | 96.69 | 2.68 | 0.02 | 1.35 | 96.69 | 2.68 | 0.02 | 1.35 |
| NMP22 | 85.59 | 2.17 | −1.59 | 1.88 | 85.21 | 5.54 | −1.59 | 3.56 |
| FISH | 89.58 | −7.19 | −6.75 | 6.97 | 89.58 | −7.19 | −6.39 | 6.79 |
| Cxbladder Detect | 84.11 | −1.38 | 5.50 | 3.44 | 84.20 | 1.99 | −1.92 | 1.95 |
| Mean for method | 88.99 | −0.93 | −0.70 | 3.41 | 88.92 | 0.75 | −2.47 | 3.42 |
| MLP | ||||||||
| Cytology | 95.87 | 1.55 | 0.02 | 0.79 | 95.87 | 2.68 | 0.02 | 1.35 |
| NMP22 | 86.35 | 5.54 | −1.59 | 3.56 | 83.19 | 5.54 | −1.59 | 3.56 |
| FISH | 89.25 | −9.44 | −6.87 | 8.16 | 88.60 | −7.19 | −6.39 | 6.79 |
| Cxbladder Detect | 82.78 | 0.87 | −2.39 | 1.63 | 82.47 | 1.99 | −1.92 | 1.95 |
| Mean for method | 88.56 | −0.37 | −2.71 | 3.53 | 87.53 | −2.47 | −2.47 | 3.42 |
Difference = measured – imputed