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. 2014 Oct 27;2(4):772–784. doi: 10.3390/vaccines2040772

Table 1.

Vaccine treatments administered to A/J mice via intramuscular inoculation and their response to challenge with Yersinia pestis (CO92) at various days post booster vaccination (dpb) at a dosage of 1.4 × 104 mouse LD50s. Risk ratios are calculated in relation to RCN-F1/V307 at day 56 dpb. Lower and upper 95% indicate 95% confidence intervals on the risk ratio.

Treatment DPB % Survival Risk Ratio Prob > Chisq Lower 95% Upper 95%
Control 7 0 9.04 0.01 1.71 66.63
14 0 4.15 0.09 0.80 30.34
28 0 7.27 0.02 1.39 53.13
56 0 4.31 0.08 0.84 31.24
RCN-F1 7 33 2.70 0.24 0.53 19.47
14 50 1.56 0.62 0.26 11.83
28 67 0.85 0.87 0.10 7.08
56 50 1.46 0.67 0.24 11.11
RCN-V307 7 33 2.52 0.27 0.49 18.24
14 17 2.88 0.18 0.61 20.23
28 17 4.70 0.05 1.00 33.00
56 0 5.90 0.02 1.33 40.88
RCN-F1 + RCN-V307 7 33 1.88 0.45 0.37 13.58
14 100 0.00 0.06 0.00 1.15
28 100 0.00 0.06 0.00 1.15
56 33 1.87 0.46 0.37 13.50
RCN-F1/V307 7 17 3.78 0.09 0.81 26.48
14 50 1.53 0.64 0.25 11.59
28 67 0.80 0.82 0.10 6.67
56 67 1.00