Table 3.

Vaccine treatments administered to A/J mice via intramuscular inoculation and their response to challenge with two dosages (low—1.4 × 10⁴ mouse LD₅₀s and high—1.4 × 10⁵ mouse LD₅₀s) of an F1 negative strain of Yersinia pestis (Java 9, YERS022) at 21 and 42 days post booster vaccination (dpb). Risk ratios are calculated in relation to RCN F1/V307 at the high dose and 42 days dpb.

Treatment	Challenge Dose	DPB	% Survival	Risk Ratio	Prob > Chisq	Lower 95%	Upper 95%
RCN-F1	low	21	0	3.69	0.08	0.85	25.26
		42	0	4.59	0.04	1.04	31.77
	high	21	0	5.00	0.03	1.12	34.67
		42	0	9.70	0.00	2.16	67.82
RCN-F1 + RCN-V307	low	21	50	1.51	0.65	0.25	11.48
		42	33	2.36	0.31	0.46	17.02
	high	21	0	8.29	0.01	1.87	57.44
		42	50	1.69	0.56	0.28	12.84
RCN-F1/V307	low	21	50	1.56	0.62	0.26	11.84
		42	50	1.69	0.56	0.28	12.84
	high	21	50	1.44	0.68	0.24	10.96
		42	67	1.00