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. 2014 May 14;2(2):354–379. doi: 10.3390/vaccines2020354

Figure 1.

Figure 1

Optimization of DNA expression and delivery: from bench to bedside. Several steps are necessary to improve the efficiency of DNA as vaccine including RNA/codon optimization of the gene, the use of optimized expression vectors, and combinations of DNA vaccine with molecular adjuvants to increase immunogenicity and using different delivery methods and sites.