Table III.

Measurements of tibia mechanical properties in male placebo (vehicle)- and etidronate-treated Enpp1^−/− and WT mice.

	WT		Enpp1−/−
	Placebo	Etidronate	Placebo	Etidronate
Stiffness (N/mm)	44.56±7.08	48.82±23.43	22.42±7.19a,d	22.52±6.64a,e
Load at failure (N)	17.22±2.90	15.34±4.13	9.21±1.38a,e	8.89±1.84a,e
Work to failure (J)	0.0066±0.00066	0.0064±0.0019	0.0033±0.00081a,e	0.0035±0.00092a,e
Load at fracture (N)	1.72±0.29	1.53±0.41	0.92±0.14a,e	0.89±0.18a,e
Work to fracture (J)	0.0069±0.00087	0.0086±0.0019b,c	0.0038±0.0011a,e	0.0044±0.00082a,e
Work post-failure (J)	0.00037±0.00041	0.0023±0.0014b,d	0.00055±0.00082	0.00088±0.0012a,c
Yield (N)	14.41±3.95	12.97±4.42	6.96±1.45a,e	7.11±1.79a,d

Results are expressed as the means ± SEM.

^aSignificant difference compared to wild-type (WT) mice

^bsignificant difference compared to placebo-treated mice;

^cP<0.05;

^dP<0.01;

^eP<0.001.