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Effect of CCN5 on the profibrotic phenotype of fibroblasts induced by transforming growth factor-β (TGF-β1). The isolated fibroblasts were transfected or not with LV-CCN5 prior to TGF-β1 stimulation. The expression levels of α-smooth muscle actin (α-SMA), a specific marker of myofibroblasts, were analyzed by western blotting (A). mRNA (B) and protein levels (C) of CLO1A1 were asssessed. The total collagen concentration was assessed using a Sircol assay kit (D). *P<0.05.
