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Functional test: Putative conformations of the complex with ligand in LBD for Type II estrogen to be “antiestrogenic” with regard to helix 12 positioning. The assay discriminates between ligands (A), which allow helix 12 to seal the LBD or not (B and C). Sealing of helix 12 over the LBD is important for the ability of the ligands to trigger apoptosis.
Reproduced with permission from (165).
