Table 3.

miRNAs and expression of their predicted targets as assessed by immunohistochemistry (IPX) for the initial cohort of 35 BRCA1 and 52 sporadic basal cancers

miRNA	miRNA expression up or down in BRCA1 vs. sporadic cancers	Fold change miRNA	adjusted p value (BRCA1 vs. sporadic)	Predicted target gene	IPX expression up or down in BRCA1 vs. sporadic cancers	Positive IPX in BRCA1, n (%)	Positive IPX in sporadic, n (%)	p value (chi square) positive or negative on IPX	p value (Mann–Whitney) on IPX score out of 7
hsa-miR-509-5p	Up	2.53	0.004	FOXP1	Down	6 (30 %)	37 (76 %)	<0.001	<0.001
hsa-miR-1285	Up	2.68	0.042
hsa-miR-1826	Up	3.02	<0.001
hsa-miR-220b	Up	3.76	<0.001
hsa-miR-1826	Up	3.02	<0.001	Cyclin D1	Down	8 (36 %)	30 (65 %)	0.025	0.004
hsa-miR-576-3p	Up	3.26	0.001
hsa-miR-638	Up	3.04	0.036
hsa-miR-30c-1*	Up	4.51	<0.001	NRP1	Down	2 (10 %)	23 (50 %)	0.002	0.003
hsa-miR-1285	Up	2.69	0.043
hsa-miR-129-3p	Up	6.03	<0.001
hsa-miR-29a*	Down	3.12	<0.001	CD99	Up	17 (85 %)	7 (37 %)	0.002	0.005
hsa-miR-130b*	Down	2.95	<0.006
hsa-miR-132*	Down	2.48	0.024
hsa-miR-340*	Down	3.09	0.028