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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5296–5306. doi: 10.1021/jm200543y

Table 1.

In vitro antimalarial activity of prodiginine analogs where the non alkylated terminal pyrrole (left hand side) has been substituted

graphic file with name nihms-310248-t0008.jpg

Compd R1 R2 R3 IC50 (nM)
Cytotoxicity
(nM)
D6 Dd2
CQ - - - 11 135 16000
18 graphic file with name nihms-310248-t0009.jpg CH3 CH3 4250 4950 < 125
19 graphic file with name nihms-310248-t0010.jpg n-C11H23 H 4060 6150 3410
20 graphic file with name nihms-310248-t0011.jpg n-C11H23 H 10470 15750 3580
21 graphic file with name nihms-310248-t0012.jpg CH3 CH3 19410 13640 7950
22 graphic file with name nihms-310248-t0013.jpg n-C11H23 H 2920 3810 980
23 graphic file with name nihms-310248-t0014.jpg CH3 CH3 > 25000 > 25000 3530
24 graphic file with name nihms-310248-t0015.jpg n-C11H23 H 5940 7770 2120
25 graphic file with name nihms-310248-t0016.jpg CH3 CH3 > 25000 > 25000 3890