Table 1.
| ||||||
---|---|---|---|---|---|---|
Compd | R1 | R2 | R3 | IC50 (nM) |
Cytotoxicity (nM) |
|
D6 | Dd2 | |||||
CQ | - | - | - | 11 | 135 | 16000 |
18 | CH3 | CH3 | 4250 | 4950 | < 125 | |
19 | n-C11H23 | H | 4060 | 6150 | 3410 | |
20 | n-C11H23 | H | 10470 | 15750 | 3580 | |
21 | CH3 | CH3 | 19410 | 13640 | 7950 | |
22 | n-C11H23 | H | 2920 | 3810 | 980 | |
23 | CH3 | CH3 | > 25000 | > 25000 | 3530 | |
24 | n-C11H23 | H | 5940 | 7770 | 2120 | |
25 | CH3 | CH3 | > 25000 | > 25000 | 3890 |