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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5296–5306. doi: 10.1021/jm200543y

Table 4.

In vivo antimalarial efficacy of prodiginine analogs in P. yoelii murine infection



Compd
Dose
mg/kg/day		 No. of
treated
mice
% Group mean
weight; Day3
vs Day0
% Parasitemia
reduction vs controls;
Day3
Controls - 5 100.8 0
41 5 5 101.2 38
41 25 5 105.0 90
48 5 5 100.1 90
48 25 4 92.4 100
49 5 5 101.5 97
49 25 4 84.5 100
57 5 5 102.9 94
57 25 5 87.6 100
58 5 5 100.3 99
58 25 4 96.0 100
60 5 5 100.2 72
60 25 3 93.4 100
66 5 5 107.5 92
66 25 5 102.5 100