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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Cancer Cell Microenviron. 2014 Oct 10;1(5):e295. doi: 10.14800/ccm.295

Figure 1. Possible mechanisms of GSC pool expansion post TMZ therapy.

Figure 1

In our experimental models we observed expansion of GSC frequency after long-term treatment with the therapeutic dose of TMZ (50 µM). We hypothesize three scenarios that can explain such expansion: 1) Selection, where TMZ can selectively deplete less resistant non-GSC GBM cells, thus expanding the GSC pool in a given tumor population; 2) Expansion, where TMZ therapy can promote proliferation in the GSC pool; 3) Conversion, where TMZ can reprogram the non-GSCs into GSC-like cells.