Effects of UFP-101 and fluoxetine in the forced swim and tail suspension procedures. (a) Mean (± s.e.m.) floating time spent by mice in the forced swim procedure after intrahippocampal infusions of artificial cerebrospinal fluid (acsf, n = 7) or UFP-101 (1 and 3 nmol, n = 8 per dose). (b) Mean (± s.e.m.) floating time after intraperitoneal administration of vehicle (Veh, n = 8) or fluoxetine (10 mg/kg, n = 8). Mean (± s.e.m.) latency to the first immobility (c) and the total immobility time (c′) in the tail suspension test following intrahippocampal infusions of acsf (n = 6) or UFP-101 (3 nmol, n = 8). Mean (± s.e.m.) latency to the first immobility (d) and the total immobility time (d′) following intraperitoneal administration of vehicle (Veh, n = 7) or fluoxetine (10 and 30 mg/kg, n = 8 per dose). *significantly different form corresponding control group, P < 0.05 Student t-test or ANOVA followed by Dunnett’s test.